Etazolate hydrochloride

Cat. No. 0438

Etazolate hydrochloride C14H19N5O2.HCl [35838-58-5]

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Chemical Name: 1-Ethyl-4-[(1-methylethylidene)hydrazino]-1H-pyrazolo-[3,4-b]-pyridine-5-carboxylic acid, ethyl ester hydrochloride

Biological Activity

Phosphodiesterase inhibitor, selective for PDE4 (IC50 = 2.0 μM).

Technical Data

M.Wt:
325.8
Formula:
C14H19N5O2.HCl
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
35838-58-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Ahluwalia and Nicholson et al (1991) Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. TiPS 12 19. PMID: 1848733.

Rhoads (1982) Selective inhibition of cyclic AMP and cyclic GMP phosphodiesterases of cardiac nuclear fraction. Biochem.Pharmacol. 31 665. PMID: 6177320.

Chesin et al (1972) 1-Ethyl-4-(isopropylidenehydrazinol-H-pyrazolo-(3,4-b)-pyridin-5-carboxylic acid, ethyl ester, hydrochloride (SQ 20009) - potent new inhibitor of cyclic 3'5-nucleotide phosphodiesterase. Biochem.Pharmacol. 21 2443. PMID: 4345859.

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Keywords: Etazolate hydrochloride, supplier, PDE4, inhibitors, inhibits, PDE, Phosphodiesterases, Tocris Bioscience, Phosphodiesterase Inhibitor products

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