Cat. No. 2285
Alternative Name: Goe 6983
Chemical Name: 3-[1-[3-(Dimethylamino)propyl]-5-me
Biological ActivityBroad spectrum protein kinase C (PKC) inhibitor (IC50 values are 7, 7, 6, 10, 60 and 20000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ and PKCμ respectively). Displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury. Optimizes naïve human pluripotent stem cell growth and viability following naïve cell derivation from primed ESCs and iPSCs using naïve human stem cell medium (NHSM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Gafni et al (2013) Derivation of novel human ground state naive pluripotent stem cells. Nature 504 282. PMID: 24172903.
Young et al (2005) Go 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury. Cardiovasc.Drug Rev. 23 255. PMID: 16252018.
Peterman et al (2004) Go 6983 exerts cardioprotective effects in myocardial ischemic/reperfusion. J.Cardiovasc.Pharmacol. 43 645. PMID: 15071351.
Gschwendt et al (1996) Inhibition of protein kinase C μ by various inhibitors. Differentiation from protein kinase c isozymes. FEBS Lett. 392 77. PMID: 8772178.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for Go 6983 include:
Pakpour et al (2013) Protein kinase C-dependent signaling controls the midgut epithelial barrier to malaria parasite infection in anopheline mosquitoes. PLoS One 8 e76535. PMID: 24146884.
Rajendran et al (2013) Inhibition of protein kinase C signaling maintains rat embryonic stem cell pluripotency. J Biol Chem 288 24351. PMID: 23846691.
Vliet et al (2013) Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL). J Biol Chem 288 27519. PMID: 23918927.
Dutta et al (2011) Self-renewal versus lineage commitment of embryonic stem cells: protein kinase C signaling shifts the balance. Stem Cells 29 618. PMID: 21308862.
View Related Products by Product Action
Keywords: Go 6983, supplier, Broad, spectrum, PKC, inhibitors, Protein, Kinases, C, Go6983, Goe6983, stem, cells, naive, Tocris Bioscience, Protein Kinase C Inhibitor products
Find multiple products by catalog number
New Products in this Area
Selective ATP competitive SphK1 and 2 inhibitor; cell permeableAkti-1/2
Potent and selective dual Akt1 and 2 inhibitorVX 680
High affinity and selective Aurora kinase inhibitorImatinib mesylate
Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kitTGX 221
Potent and selective PI 3-kinase β inhibitorPF 543 hydrochloride
Potent and selective SphK1 inhibitorJX 06
Potent and selective PDK1/2/3 inhibitorMRT 68601 hydrochloride
Potent TBK1 inhibitorAzoramide
Unfolded protein response (UPR) modulatorLCB 03-0110 dihydrochloride
Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and SykCCT 241533 dihydrochloride
Potent Chk2 inhibitorIRAK1/4 Inhibitor I
IRAK4 and IRAK1 inhibitorCentrinone
High affinity and selective PLK4 inhibitorAZD 3147
Potent and selective dual mTORC1 and 2 inhibitor; orally bioavailableTilfrinib
Potent and selective breast tumor kinase (Brk) inhibitorProstratin
PKC activator; also NF-κB activator
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.