Go 6983

Cat. No. 2285

Go 6983 C26H26N4O3 [133053-19-7]

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Alternative Name: Goe 6983

Chemical Name: 3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

Biological Activity

Broad spectrum protein kinase C (PKC) inhibitor (IC50 values are 7, 7, 6, 10, 60 and 20000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ and PKCμ respectively). Displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury. Optimizes naïve human pluripotent stem cell growth and viability following naïve cell derivation from primed ESCs and iPSCs using naïve human stem cell medium (NHSM).

Technical Data

M.Wt:
442.51
Formula:
C26H26N4O3
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
133053-19-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Gafni et al (2013) Derivation of novel human ground state naive pluripotent stem cells. Nature 504 282. PMID: 24172903.

Young et al (2005) Go 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury. Cardiovasc.Drug Rev. 23 255. PMID: 16252018.

Peterman et al (2004) Go 6983 exerts cardioprotective effects in myocardial ischemic/reperfusion. J.Cardiovasc.Pharmacol. 43 645. PMID: 15071351.

Gschwendt et al (1996) Inhibition of protein kinase C μ by various inhibitors. Differentiation from protein kinase c isozymes. FEBS Lett. 392 77. PMID: 8772178.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Go 6983 include:

Devinney et al (2015) Phrenic long-term facilitation requires PKCθ activity within phrenic motor neurons. Proc Natl Acad Sci U S A 35 8107. PMID: 26019328.

Shakiba et al (2015) CD24 tracks divergent pluripotent states in mouse and human cells. J Biol Chem 6 7329. PMID: 26076835.

Toda and Huganir (2015) Regulation of AMPA receptor phosphorylation by the neuropeptide PACAP38. Nat Commun 112 6712. PMID: 25964356.

Cavaliere et al (2014) NMDA modulates oligodendrocyte differentiation of subventricular zone cells through PKC activation. Cell Signal 7 261. PMID: 24391542.

Kuan et al (2014) Ets and GATA Transcription Factors Play a Critical Role in PMA-Mediated Repression of the ckβ Promoter via the Protein Kinase C Signaling Pathway. Biol Chem 9 e113485. PMID: 25490397.

Yi et al (2014) Systematic analysis of bacterial effector-postsynaptic density 95/disc large/zonula occludens-1 (PDZ) domain interactions demonstrates Shigella OspE protein promotes protein kinase C activation via PDLIM proteins. Neuron 289 30101. PMID: 25124035.

Atwood et al (2013) GLI activation by atypical protein kinase C Ι/λ regulates the growth of basal cell carcinomas. J Neurosci 494 484. PMID: 23446420.

Pakpour et al (2013) Protein kinase C-dependent signaling controls the midgut epithelial barrier to malaria parasite infection in anopheline mosquitoes. PLoS One 8 e76535. PMID: 24146884.

Rajendran et al (2013) Inhibition of protein kinase C signaling maintains rat embryonic stem cell pluripotency. J Biol Chem 288 24351. PMID: 23846691.

Vliet et al (2013) Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL). J Biol Chem 288 27519. PMID: 23918927.

Baskin and Sayeski (2012) Angiotensin II mediates cell survival through upregulation and activation of the serum and glucocorticoid inducible kinase 1. BMC Complement Altern Med 24 435. PMID: 21963429.

Garrett et al (2012) γ-protocadherins control cortical dendrite arborization by regulating the activity of a FAK/PKC/MARCKS signaling pathway. PLoS One 74 269. PMID: 22542181.

Scarisbrick et al (2012) Kallikrein 6 is a novel molecular trigger of reactive astrogliosis. Front Cell Neurosci 393 355. PMID: 22505518.

Dutta et al (2011) Self-renewal versus lineage commitment of embryonic stem cells: protein kinase C signaling shifts the balance. Stem Cells 29 618. PMID: 21308862.

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Keywords: Go 6983, supplier, Broad, spectrum, PKC, inhibitors, inhibits, Protein, Kinases, C, Go6983, Goe6983, stem, cells, naive, Tocris Bioscience, Protein Kinase C Inhibitor products

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