SEW 2871

Cat. No. 2284

SEW 2871 C20H10F6N2OS [256414-75-2]

Price and Availability

For SEW 2871 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 5-[4-Phenyl-5-(trifluoromethyl)thiophen-2-yl]-3-[3-(trifluoromethyl)phenyl]1,2,4-oxadiazole

Biological Activity

Novel, potent and selective sphingosine-1-phosphate 1 (S1P1) receptor agonist. Activates S1P1 receptor with an EC50 of 13 nM, but does not activate S1P2, S1P3, S1P4 or S1P5 receptors at concentrations up to 10 μM. Cell-permeable and active in vivo.

Technical Data

M.Wt:
440.36
Formula:
C20H10F6N2OS
Solubility:
Soluble to 20 mM in DMSO and to 20 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
256414-75-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Bolick et al (2005) Sphingosine-1-phosphate prevents tumor necrosis factor-α-mediated monocyte adhesion to aortic endothelium in mice. Arterioscler.Thromb.Vasc.Biol. 25 976. PMID: 15761190.

Hale et al (2004) A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists. J.Med.Chem. 47 6662. PMID: 15615513.

Sanna et al (2004) Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. J.Biol.Chem. 279 13839. PMID: 14732717.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for SEW 2871 include:

O'Sullivan et al (2014) Sphingosine 1-phosphate (S1P) induced interleukin-8 (IL-8) release is mediated by S1P receptor 2 and nuclear factor κB in BEAS-2B cells. PLoS One 9 e95566. PMID: 24743449.

Beckham et al (2012) Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B. Int J Cancer 131 2034. PMID: 22322590.

Frias et al (2010) Native and reconstituted HDL protect cardiomyocytes from doxorubicin-induced apoptosis. Nature 85 118. PMID: 19700468.

Kim et al (2010) Isoflurane protects human kidney proximal tubule cells against necrosis via sphingosine kinase and sphingosine-1-phosphate generation. Cardiovasc Res 31 353. PMID: 20234131.

Zhang et al (2010) Sphingosine-1-phosphate prevents permeability increases via activation of endothelial sphingosine-1-phosphate receptor 1 in rat venules. Am J Nephrol 299 H1494. PMID: 20729401.

Do you know of a great paper that uses SEW 2871 from Tocris? If so please let us know.show all ▼show less ▲

View Related Products by Product Action

Keywords: SEW 2871, supplier, Cell-permeable, selective, S1P1, receptors, agonists, EDG1, sphingosine-1-phosphate, SEW2871, Tocris Bioscience, Sphingosine-1-Phosphate Receptor Agonist products

Quick Order

Find multiple products by catalog number

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs. Request copy or view PDF today.

divider line

VEGF Pathway & Anti-Angiogenic Therapy

Written by N. Ferrara & Y. Crawford

Angiogenesis Life Science Poster

A summary of antiangiogenic therapies targeting the VEGF pathway and the mechanisms of therapy resistance. Request copy today.

divider line

New Products in this Area

ZQ 16

Selective GPR84 agonist

IHR-Cy3

Potent fluorescent Smo antagonist

Ro 6842262

Potent LPA1 antagonist

AMG 853

Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonist

AM 4668

Potent FFA1 (GPR40) agonist

CATPB

FFA2 antagonist/inverse agonist

Oleanolic acid

Selective GPBA receptor (TGR5) partial agonist

PPTN hydrochloride

High affinity and selective P2Y14 antagonist

Itraconazole

SMO antagonist; acts at different binding site to cyclopamine (Cat No. 1623)

SAR 216471 hydrochloride

Potent P2Y12 antagonist; orally available

A 971432

Potent and selective S1P5 agonist

GLPG 0974

Potent FFA2 antagonist

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.