Cat. No. 0684
Chemical Name: (±)-exo-2-(6-Chloro-3-pyridinyl)-7-a
Biological ActivityHigh affinity nicotinic agonist (Ki values are 0.02 and 233 nM for α4β2 and α7 nicotinic receptors respectively). Analgesic.
Licensing InformationSold under license from the NIH, US Patent 5,314,899
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Sharples et al (2000) UB-165 implicates α4β2 nAChR in striatal dopamine release. J.Neurosci. 20 2783. PMID: 10751429.
Marks et al (1998) Differential agonist inhibition identifies multiple epibatidine binidng sites in mouse brain. J.Pharmacol.Exp.Ther. 285 377. PMID: 9536034.
Gerzarich et al (1995) Comparative pharmacology of epibatidine; a potent agonist for neuronal nicotinic acetylcholine receptors. Mol.Pharmacol. 48 774. PMID: 7476906.
Badio and Daly (1994) Epibatidine, a potent analgesic and nicotinic agonist. Mol.Pharmacol. 45 563. PMID: 8183234.
Spande et al (1992) Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity. J.Am.Chem.Soc. 114 3475.
If you know of a relevant reference for (±)-Epibatidine please let us know.
Citations are publications that use Tocris products. Selected citations for (±)-Epibatidine include:
Beckel et al (2006) Expression of functional nicotinic acetylcholine receptors in rat urinary bladder epithelial cells. J Neurosci 290 F103. PMID: 16144967.
Do you know of a great paper that uses (±)-Epibatidine from Tocris? If so please let us know.
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Keywords: (±)-Epibatidine, supplier, potent, nicotinic, agonists, Acetylcholine, Nicotinic, Receptors, Non-Selective, nAChR, Tocris Bioscience, Nicotinic Receptor (Non-selective) Agonist products