Cat. No. 1219
Chemical Name: 7-Chloro-3-methyl-3,4-dihydro-2H-1,
Biological ActivityInhibits AMPA receptor desensitization and enhances cognition by a related mechanism. More able to cross the blood-brain barrier than cyclothiazide (Cat. No. 0713).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Impagnatiello et al (1997) 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide: a partial modulator of AMPA receptor desensitization devoid of neurotoxicity. Proc.Natl.Acad.Sci.U.S.A. 94 7053. PMID: 9192690.
Thompson et al (1995) 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA 21), a congener of aniracetam, potently abates pharmacologically induced cognitive impairments in patas monkeys. Proc.Natl.Acad.Sci.U.S.A. 92 7667. PMID: 7644474.
Zivkovic et al (1995) 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA 21): a benzothiadiazine derivative that enhances cognition by attenuating DL-α-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid (AMPA) receptor desensitization. J.Pharmacol.Exp.Ther. 272 300. PMID: 7815345.
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Keywords: IDRA 21, supplier, inhibitors, inhibits, AMPA, receptor, desensitization, desensitisation, Glutamate, Receptors, iGlur, Ionotropic, IDRA21, Tocris Bioscience, AMPA Receptor Inhibitor products
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