Cat. No. 1218
Chemical Name: N-Pentanoyl-2-benzyltryptamine
Biological ActivityA relatively potent MT2 melatonin receptor antagonist (pKi value = 8.03), displaying 89- and 229-fold selectivity over MT1 and GPR50 (melatonin-related orphan receptor) respectively.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Ting et al (1999) Molecular and pharmacological evidence for MT1 melatonin receptor subtype in the tail artery of juvenile Wistar rats. Br.J.Pharmacol. 127 987. PMID: 10433507.
Teh and Sugden (1998) Comparison of the relationships of melatonin receptor agonists and antagonists; lengthening the N-acyl side chain has differing effects on potency on Xenopus melanophores. Naunyn Schmiedebergs Arch.Pharmacol. 358 522. PMID: 9840420.
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Citations are publications that use Tocris products. Selected citations for DH 97 include:
Kojima et al (2011) Melatonin inhibits tachykinin NK2 receptor-triggered 5-HT release from guinea pig isolated colonic mucosa. Br J Pharmacol 162 1179. PMID: 21091649.
Sjöblom et al (2003) Melatonin-induced calcium signaling in clusters of human and rat duodenal enterocytes. BMC Neurosci 284 G1034. PMID: 12584110.
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Keywords: DH 97, supplier, MT2, receptor, antagonist, Receptors, Melatonin, DH97, Tocris Bioscience, Melatonin Receptor Antagonist products
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