Cat. No. 1218
Chemical Name: N-Pentanoyl-2-benzyltryptamine
Biological ActivityA relatively potent MT2 melatonin receptor antagonist (pKi value = 8.03), displaying 89- and 229-fold selectivity over MT1 and GPR50 (melatonin-related orphan receptor) respectively.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Ting et al (1999) Molecular and pharmacological evidence for MT1 melatonin receptor subtype in the tail artery of juvenile Wistar rats. Br.J.Pharmacol. 127 987. PMID: 10433507.
Teh and Sugden (1998) Comparison of the relationships of melatonin receptor agonists and antagonists; lengthening the N-acyl side chain has differing effects on potency on Xenopus melanophores. Naunyn Schmiedebergs Arch.Pharmacol. 358 522. PMID: 9840420.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for DH 97 include:
Kojima et al (2011) Melatonin inhibits tachykinin NK2 receptor-triggered 5-HT release from guinea pig isolated colonic mucosa. Br J Pharmacol 162 1179. PMID: 21091649.
Sjöblom et al (2003) Melatonin-induced calcium signaling in clusters of human and rat duodenal enterocytes. BMC Neurosci 284 G1034. PMID: 12584110.
Do you know of a great paper that uses DH 97 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: DH 97, supplier, MT2, receptor, antagonist, Receptors, Melatonin, DH97, Tocris Bioscience, Melatonin Receptor Antagonist products
Find multiple products by catalog number
New Products in this Area
Potent FFA1 (GPR40) agonistCATPB
FFA2 antagonist/inverse agonistOleanolic acid
Selective GPBA receptor (TGR5) partial agonistPPTN hydrochloride
High affinity and selective P2Y14 antagonistItraconazole
SMO antagonist; acts at different binding site to cyclopamine (Cat No. 1623)SAR 216471 hydrochloride
Potent P2Y12 antagonist; orally availableA 971432
Potent and selective S1P5 agonistGLPG 0974
Potent FFA2 antagonistOgerin
Selective positive allosteric modulator at GPR68BGC 20-1531 hydrochloride
High affinity and selective EP4 antagonistMontelukast sodium
CysLT1 and GPR17 antagonist
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.