Cat. No. 1215
Chemical Name: 6-Methyl-2-(phenylazo)-3-pyridinol
Biological ActivityA highly selective antagonist for the mGlu5 metabotropic glutamate receptor subtype; displays an IC50 value of 0.4 μM at hmGlu5 compared with > 30 μM at hmGlu1b, hmGlu2, hmGlu4, hmGlu6, hmGlu7 and hmGlu8.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Varney et al (1999) SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5. J.Pharmacol.Exp.Ther. 290 170. PMID: 10381773.
Varney et al (1999) Characterisation of SIB-1757 and SIB-1893: highly selective antagonists at metabotropic glutamate receptor subtype 5. Br.J.Pharmacol. 126 248P.
If you know of a relevant reference for SIB 1757 please let us know.
Citations are publications that use Tocris products. Selected citations for SIB 1757 include:
El-Kouhen et al (2006) Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist. Br J Pharmacol 149 761. PMID: 17016515.
Do you know of a great paper that uses SIB 1757 from Tocris? If so please let us know.
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Keywords: SIB 1757, supplier, selective, mGlu5, mGluR5, antagonist, Group, I, Receptors, Glutamate, Metabotropic, SIB1757, Tocris Bioscience, Glutamate (Metabotropic) Group I Receptor Antagonist products