EIT hydrobromide

Cat. No. 0873

EIT hydrobromide C3H8N2S.HBr [1071-37-0]

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Chemical Name: (S)-Ethylisothiourea hydrobromide

Biological Activity

Potent, selective and reversible inhibitor of isoform II NO synthase (IC50 = 13 nM; approximately 20- and 30-fold selective over isoforms I and III respectively).

Technical Data

Soluble to 100 mM in water
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service

References are publications that support the products' biological activity.

Squadrito et al (1996) Effects of S-ethylisothiourea, a potent inhibitor of nitirc oxide synthase, alone or in combination with a nitric oxide donor in splanchnic artery occlusion shock. Br.J.Pharmacol. 119 23. PMID: 8872352.

Nakane et al (1995) Novel potent and selective inhibitors of inducible nitric oxide synthase. Mol.Pharmacol. 47 831. PMID: 7536889.

Garvey et al (1994) Potent and selective inhibition of human nitric oxide synthase. J.Biol.Chem. 269 26669. PMID: 7523409.

If you know of a relevant reference for EIT hydrobromide please let us know.

Citations are publications that use Tocris products.

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Keywords: EIT hydrobromide, supplier, Selective, iNOS, inhibitors, inhibits, arginine, binding, site, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases, Tocris Bioscience, iNOS Inhibitor products

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