Cat. No. 0841

DTG C15H17N3 [97-39-2]

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Chemical Name: 1,3-Di-(2-tolyl)guanidine

Biological Activity

Displays high and roughly equal affinity for both σ1 and σ2 receptors.

Technical Data

Soluble to 25 mM in ethanol and to 25 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

He et al (1993) Synthesis and binding characteristics of potential SPECT imaging agents for σ1 and σ2 binding sites. J.Med.Chem. 36 566. PMID: 8496936.

Quirion et al (1992) A proposal for the classification of sigma binding sites. TiPS 13 85. PMID: 1315463.

If you know of a relevant reference for DTG please let us know.

Citations are publications that use Tocris products. Selected citations for DTG include:

Pan et al (2014) σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons. Neuroscience 350 290. PMID: 24891452.

Hall et al (2009) Delayed treatments for stroke influence neuronal death in rat organotypic slice cultures subjected to oxygen glucose deprivation. PLoS One 164 470. PMID: 19723565.

Do you know of a great paper that uses DTG from Tocris? If so please let us know.

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Keywords: DTG, supplier, High, affinity, ligand, σ1, sigma1, σ2, sigma2, General, Receptors, Tocris Bioscience, Sigma-Related Ligand products

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