Cat. No. 0743
Chemical Name: N,N-Diethyl-2-[4-(phenylmethyl)phen
Biological ActivityBinds with high affinity to the antiestrogen binding site but not to the estrogen receptor. Induces of sterol accumulation in MCF7 cells. An inhibitor of histamine binding at the intracellular histamine (Hlc) site.
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Kedjouar et al (2004) Molecular characterization of the microsomal tamoxifen binding site. J.Biol.Chem. 279 34048. PMID: 15175332.
Sturman et al (1994) Modulation of the intracellular and H3-histamine receptors and chemically-induced seizures in mice. Agents Actions 41 C68. PMID: 7976808.
Brandes et al (1990) Histamine as an intracellular messenger. Biochem.Pharmacol. 40 1677. PMID: 2242003.
Brandes and Hermonat (1984) A diphenylmethane derivative specific for the antiestrogen binding site found in rat liver microsomes. Biochem.Biophys.Res.Commun. 123 724. PMID: 6548377.
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Keywords: DPPE fumarate, supplier, Ligand, antiestrogen, binding, site, inhibitors, inhibits, histamine, intracellular, ER, ERR, Estrogen, Receptors, Histaminergic-, Compounds, Tocris Bioscience, Histaminergic-Related Compound Inhibitor products