DPPE fumarate

Cat. No. 0743

DPPE fumarate C19H25NO.C4H4O4 [1185241-83-1]

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Chemical Name: N,N-Diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine fumarate

Biological Activity

Binds with high affinity to the antiestrogen binding site but not to the estrogen receptor. Induces of sterol accumulation in MCF7 cells. An inhibitor of histamine binding at the intracellular histamine (Hlc) site.

Technical Data

Soluble to 100 mM in DMSO
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

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References are publications that support the products' biological activity.

Kedjouar et al (2004) Molecular characterization of the microsomal tamoxifen binding site. J.Biol.Chem. 279 34048. PMID: 15175332.

Sturman et al (1994) Modulation of the intracellular and H3-histamine receptors and chemically-induced seizures in mice. Agents Actions 41 C68. PMID: 7976808.

Brandes et al (1990) Histamine as an intracellular messenger. Biochem.Pharmacol. 40 1677. PMID: 2242003.

Brandes and Hermonat (1984) A diphenylmethane derivative specific for the antiestrogen binding site found in rat liver microsomes. Biochem.Biophys.Res.Commun. 123 724. PMID: 6548377.

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Citations are publications that use Tocris products.

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Keywords: DPPE fumarate, supplier, Ligand, antiestrogen, binding, site, inhibitors, inhibits, histamine, intracellular, ER, ERR, Estrogen, Receptors, Histaminergic-, Compounds, Tocris Bioscience, Histaminergic-Related Compound Inhibitor products

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Histamine Scientific Review

Written by I. de Esch & R. Leurs

Histamine Receptors Scientific Review

Our Histamine review gives an overview of the different histamine receptor subtypes, as well as highlighting pharmacological ligands for their study. View PDF today.

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