Cat. No. 0743
Chemical Name: N,N-Diethyl-2-[4-(phenylmethyl)phen
Biological ActivityBinds with high affinity to the antiestrogen binding site but not to the estrogen receptor. Induces of sterol accumulation in MCF7 cells. An inhibitor of histamine binding at the intracellular histamine (Hlc) site.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
on-line. Please contact Customer Service
Kedjouar et al (2004) Molecular characterization of the microsomal tamoxifen binding site. J.Biol.Chem. 279 34048. PMID: 15175332.
Sturman et al (1994) Modulation of the intracellular and H3-histamine receptors and chemically-induced seizures in mice. Agents Actions 41 C68. PMID: 7976808.
Brandes et al (1990) Histamine as an intracellular messenger. Biochem.Pharmacol. 40 1677. PMID: 2242003.
Brandes and Hermonat (1984) A diphenylmethane derivative specific for the antiestrogen binding site found in rat liver microsomes. Biochem.Biophys.Res.Commun. 123 724. PMID: 6548377.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses DPPE fumarate from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: DPPE fumarate, supplier, Ligand, antiestrogen, binding, site, inhibitors, inhibits, histamine, intracellular, ER, ERR, Estrogen, Receptors, Histaminergic-, Compounds, Tocris Bioscience, Histaminergic-Related Compound Inhibitor products