Doxepin hydrochloride

Cat. No. 0508

Doxepin hydrochloride C19H21NO.HCl [1229-29-4]

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Chemical Name: 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin hydrochloride

Biological Activity

Highly potent H1 histamine receptor antagonist (Kd = 310 pM) and tricyclic antidepressant. Also binds to the H4 histamine receptor (pKi = 6.79).

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>99 %
Store at RT


Other Information

  • This compound is a mixture of E/Z isomers (ratio: 85:15)

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Nguyen et al (2001) Discovery of a novel member of the histamine receptor family. Mol.Pharmacol. 59 427. PMID: 11179435.

Lurchins (1983) Review of clinical and animal studies comparing the cardiovascular effects of doxepin and other tricyclic antidepressants. Am.J.Psychiatry 140 1006. PMID: 6346907.

Tran et al (1981) [3H]Doxepin interactions with histamine H1-receptors and other sites in guinea pig brain homogenates. Eur.J.Pharmacol. 70 501. PMID: 7238574.

Merck Index 12 3492.

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Citations are publications that use Tocris products.

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Keywords: Doxepin hydrochloride, supplier, potent, H1, antagonists, binds, H4, Receptors, Histamine, histaminergic, Tocris Bioscience, Histamine H1 Receptor Antagonist products

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