UBP1112

Cat. No. 1369

UBP1112 C10H14NO5P [339526-74-8]

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Chemical Name: α-Methyl-3-methyl-4-phosphonophenylglycine

Biological Activity

A selective group III mGlu receptor antagonist (apparent Kd values are 5.1 and 488 μM for group III and group II mGlu receptors respectively; IC50 > 1 mM for group I, NMDA, AMPA and kainate receptors).

Technical Data

M.Wt:
259.2
Formula:
C10H14NO5P
Solubility:
Soluble to 100 mM in 1eq. NaOH
Purity:
>99 %
Storage:
Store at RT
CAS No:
339526-74-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Miller et al (2003) Phenylglycine derivatives as antagonists of group III metabotropic glutamate receptors expressed on neonatal rat primary afferent terminals. Br.J.Pharmacol. 139 1523. PMID: 12922940.

Conway et al (2001) Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors. Bioorg.Med.Chem.Lett. 11 777. PMID: 11277518.

If you know of a relevant reference for UBP1112 please let us know.

Citations are publications that use Tocris products. Selected citations for UBP1112 include:

Govea et al (2012) Group III metabotropic glutamate receptors and transient receptor potential vanilloid 1 co-localize and interact on nociceptors. J Biol Chem 217 130. PMID: 22609935.

Proudfoot et al (2006) Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain. Curr Biol 16 1591. PMID: 16920620.

Do you know of a great paper that uses UBP1112 from Tocris? If so please let us know.

Keywords: UBP1112, supplier, Group, III, antagonists, Receptors, mGlu4, mGlu6, mGlu7, mGlu8, mGlu4R, mGlu6R, mGlu7R, mGlu8R, Glutamate, Metabotropic, UBP, 1112, Tocris Bioscience, Glutamate (Metabotropic) Group III Receptor Antagonist products

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