ZM 39923 hydrochloride
Cat. No. 1367
Chemical Name: 3-benzylisopropylamino-1-naphthalen
Biological ActivityPotent, selective inhibitor of Janus tyrosine kinase 3 (JAK3). pIC50 values are 7.1, 5.6, 4.4, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. Breaks down in neutral buffer (t½ = 36 mins, pH 7.43, 25°C) to form ZM 449829 (Cat. No. 1366).
Licensing InformationSold with the permission of AstraZeneca Ltd.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Brown et al (2000) Naphthyl ketones: a new class of janus kinase 3 inhibitors. Bioorg.Med.Chem.Lett. 10 575. PMID: 10741557.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for ZM 39923 hydrochloride include:
Rogers and Gahring (2015) Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways. Autophagy 10 e0143319. PMID: 26619345.
Schaertl et al (2010) A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitors. J Biomol Screen 15 478. PMID: 20395409.
Do you know of a great paper that uses ZM 39923 hydrochloride from Tocris? If so please let us know.
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Keywords: ZM 39923 hydrochloride, supplier, Potent, selective, JAK3, inhibitors, inhibits, Janus, Activated, Kinase, JAK, Kinases, ZM39923, AstraZeneca, Tocris Bioscience, JAK Inhibitor products
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