DNQX

Cat. No. 0189

DNQX
 C8H4N4O6 [2379-57-9]

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Chemical Name: 6,7-Dinitroquinoxaline-2,3-dione

Biological Activity

Selective non-NMDA receptor antagonist. DNQX disodium salt (Cat. No. 2312) also available.

Technical Data

M.Wt:
252.14
Formula:
C8H4N4O6
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
2379-57-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Watkins et al (1990) Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. TiPS 11 25. PMID: 2155495.

Honore et al (1988) Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science 241 701. PMID: 2899909.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for DNQX include:

Dorris et al (2015) Intrinsic excitability varies by sex in prepubertal striatal medium spiny neurons. J Neurophysiol 113 720. PMID: 25376786.

Haj-Yasein et al (2015) Deletion of aquaporin-4 increases extracellular K(+) concentration during synaptic stimulation in mouse hippocampus. Brain Struct Funct 220 2469. PMID: 24744149.

Liu et al (2015) Morphological and physiological evidence of a synaptic connection between the lateral parabrachial nucleus and neurons in the A7 catecholamine cell group in rats. J Biomed Sci 22 79. PMID: 26385355.

Malyshev et al (2015) Advantages and limitations of the use of optogenetic approach in studying fast-scale spike encoding. PLoS One 10 e0122286. PMID: 25850004.

Albrecht et al (2014) Inhibitory projections from the ventral nucleus of the trapezoid body to the medial nucleus of the trapezoid body in the mouse. Front Neural Circuits 8 83. PMID: 25120436.

Armbrust et al (2014) Mutant β-III spectrin causes mGluR1α mislocalization and functional deficits in a mouse model of spinocerebellar ataxia type 5. J Neurosci 34 9891. PMID: 25057192.

Castaño et al (2014) Fast and efficient neural conversion of human hematopoietic cells. Stem Cell Reports 3 1118. PMID: 25458894.

Dale et al (2014) Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus. J Psychopharmacol 28 891. PMID: 25122043.

Llano et al (2014) An auditory colliculothalamocortical brain slice preparation in mouse. J Neurophysiol 111 197. PMID: 24108796.

Pedroni et al (2014) Electrophysiological characterization of granule cells in the dentate gyrus immediately after birth. Front Cell Neurosci 8 44. PMID: 24592213.

Crawford et al (2013) Social stress alters inhibitory synaptic input to distinct subpopulations of raphe serotonin neurons. ACS Chem Neurosci 4 200. PMID: 23336059.

Cruz et al (2013) Ghrelin increases GABAergic transmission and interacts with ethanol actions in the rat central nucleus of the amygdala. Neuropsychopharmacology 38 364. PMID: 22968812.

Cusulin et al (2013) Characterization of corticotropin-releasing hormone neurons in the paraventricular nucleus of the hypothalamus of Crh-IRES-Cre mutant mice. PLoS One 8 e64943. PMID: 23724107.

Lau et al (2013) A conformational intermediate in glutamate receptor activation. Neuron 79 492. PMID: 23931998.

Rehak et al (2013) Low voltage activation of KCa1.1 current by Cav3-KCa1.1 complexes. PLoS One 8 e61844. PMID: 23626738.

Bajo et al (2012) Receptor subtype-dependent galanin actions on gamma-aminobutyric acidergic neurotransmission and ethanol responses in the central amygdala. Addict Biol 17 694. PMID: 21955024.

Grant et al (2012) Development of the corticothalamic projections. Front Neurosci 6 53. PMID: 22586359.

Haam et al (2012) GABA is excitatory in adult vasopressinergic neuroendocrine cells. J Neurosci 32 572. PMID: 22238092.

Crosby et al (2011) Endocannabinoids gate state-dependent plasticity of synaptic inhibition in feeding circuits. Neuron 71 529. PMID: 21835348.

Reali et al (2011) GABAergic signalling in a neurogenic niche of the turtle spinal cord. J Physiol 589 5633. PMID: 21911613.

Torborg et al (2010) Control of CA3 output by feedforward inhibition despite developmental changes in the excitation-inhibition balance. J Neurosci 30 15628. PMID: 21084618.

Llano et al (2009) Rapid and sensitive mapping of long-range connections in vitro using flavoprotein autofluorescence imaging combined with laser photostimulation. J Neurophysiol 101 3325. PMID: 19321634.

Furness et al (2008) A quantitative assessment of glutamate uptake into hippocampal synaptic terminals and astrocytes: new insights into a neuronal role for excitatory amino acid transporter 2 (EAAT2). Neuroscience 157 80. PMID: 18805467.

Guitton and Dudai (2008) Blockade of cochlear NMDA receptors prevents long-term tinnitus during a brief consolidation window after acoustic trauma. Neural Plast 2007 80904. PMID: 18301716.

Jüngling et al (2008) Neuropeptide S-mediated control of fear expression and extinction: role of intercalated GABAergic neurons in the amygdala. Neuron 59 298. PMID: 18667157.

Chen et al (2007) Changes in synaptic morphology accompany actin signaling during LTP. J Neurosci 27 5363. PMID: 17507558.

Ince-Dunn et al (2006) Regulation of thalamocortical patterning and synaptic maturation by NeuroD2. Neuron 49 683. PMID: 16504944.

Kopp et al (2006) Insufficient sleep reversibly alters bidirectional synaptic plasticity and NMDA receptor function. J Neurosci 26 12456. PMID: 17135407.

Lafourcade et al Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex. PLoS One 2 e709. PMID: 17684555.

Do you know of a great paper that uses DNQX from Tocris? If so please let us know.show all ▼show less ▲

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