Dipyridamole

Cat. No. 0691

Dipyridamole C24H40N8O4 [58-32-2]

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Chemical Name: 2,6-bis(Diethanolamino)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine

Biological Activity

Coronary vasodilator; adenosine transport inhibitor. Phosphodiesterase inhibitor (IC50 values are 0.37, 0.38, 0.45, 0.9 and 4.5 μM for PDE11, 6, 10, 5 and 8 respectively). Inhibits ENT1 and ENT2 (IC50 = 144.8 nM and Ki = 8.18 nM for ENT1).

Technical Data

M.Wt:
504.63
Formula:
C24H40N8O4
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
58-32-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Lin and Buolamwini et al (2007) Synthesis, flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibitors. J.Med.Chem. 50 3906. PMID: 17636949.

Fujishige et al (1999) Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A). J.Biol.Chem. 274 18438. PMID: 10373451.

Meester et al (1998) Pharmacological analysis of the activity of the adenosine uptake inhibitor, dipyridamole, on the sinoatrial and atrioventricular nodes of the guinea-pig. Br.J.Pharmacol. 124 729. PMID: 9690865.

Soderling et al (1998) Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. Proc.Natl.Acad.Sci.U.S.A. 95 8991. PMID: 9671792.

If you know of a relevant reference for Dipyridamole please let us know.

Citations are publications that use Tocris products. Selected citations for Dipyridamole include:

Davidson et al (2016) Alkaline Phosphatase, Soluble Extracellular Adenine Nucleotides, and Adenosine Production after Infant Cardiopulmonary Bypass PLoS One 11 e0158981. PMID: 27384524.

Cunha et al (2015) Creatine, similarly to ketamine, affords antidepressant-like effects in the tail suspension test via adenosine A1 and A2A receptor activation. Sci Rep 11 215. PMID: 25702084.

Do you know of a great paper that uses Dipyridamole from Tocris? If so please let us know.

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Keywords: Dipyridamole, supplier, adenosines, transport, inhibitors, inhibits, PDE5, 6, 10, 8, 11, ENT1, Uptake, Purine, Transporters, Pyrimidine, Equilibrative, Nucleoside, Monoamine, Neurotransmitter, Phosphodiesterases, vasodilator, Tocris Bioscience, Nucleoside Transporter Inhibitor products

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