Cat. No. 2274
Alternative Name: LY 257883
Chemical Name: (2R*,4S*)-4-(3-Phosphonopropyl)-2-p
Biological ActivityCompetitive NMDA receptor antagonist that displays moderate selectivity for NR2A-containing receptors (Ki values are 0.13, 0.47, 1.10 and 3.86 μM for NR2A, NR2B, NR2C and NR2D subunits respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Feng et al (2005) The effect of competitive antagonist chain length on NMDA receptor subunit selectivity. Neuropharmacology 48 354. PMID: 15721167.
Kinarsky et al (2005) Identification of subunit- and antagonist-specific amino acid residues in the N-methyl-D-aspartate receptor glutamate-binding pocket. J.Pharmacol.Exp.Ther. 313 1066. PMID: 15743930.
Benveniste and Mayer (1992) Effect of extracellular pH on the potency of N-methyl-D-aspartic acid receptor competitive antagonists. Mol.Pharmacol. 42 679. PMID: 1435743.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for PPPA include:
Liu et al (2015) The distinct role of NR2B subunit in the enhancement of visual plasticity in adulthood. Mol Brain 8 49. PMID: 26282667.
Do you know of a great paper that uses PPPA from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: PPPA, supplier, Competitive, NR2A, antagonists, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, LY257883, Tocris Bioscience, NMDA Receptor Antagonist products
Find multiple products by catalog number
New Products in this Area
Potent NMDA receptor antagonist; NR2A selectivecis-6-Hydroxynorketamine hydrochloride
Metabolite of ketamine (Cat.No. 3131); antidepressive
October 30 - November 3, 2016
Boston, MA, USA