Cat. No. 2272
Chemical Name: 2,3,4,10-Tetrahydro-7,10-dimethyl-2
Biological ActivityNon-peptide inhibitor of NGF that binds the NGF dimer (KD ~ 1 μM) possibly causing a conformational change. Selectively inhibits binding of NGF to p75NTR at submicromolar concentrations, and to both p75NTR and TrkA at concentrations > 5 μM. Prevents NGF-induced apoptosis in SK-N-MC cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Arkin and Wells (2004) Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat.Rev.Drug Discov. 3 301. PMID: 15060526.
Niederhauser et al (2000) NGF ligand alters NGF signaling via p75NTR and TrkA. J.Neurosci.Res. 61 263. PMID: 10900073.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Ro 08-2750 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Ro 08-2750, supplier, inhibitors, NGF, binding, p75NTR, TrkA, Neurotrophin, Receptors, p75, Trk, Receptor, Tyrosine, Kinases, RTKs, Ro08-2750, Tocris Bioscience, Trk Receptor products
Find multiple products by catalog number
New Products in this Area
Insulin sensitizer; exhibits low binding affinity at PPARγPF 6274484
High affinity and potent covalent EGFR kinase inhibitorCanertinib dihydrochloride
Potent EGFR kinase inhibitorCHMFL-FLT3-122
Potent and selective FLT3 inhibitorGW 2580
Selective cFMS kinase inhibitor; orally bioavailable
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.