Cat. No. 0483

OR-486 C6H4N2O6 [7659-29-2]

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Chemical Name: 3,5-Dinitrocatechol

Biological Activity

Potent and selective inhibitor of catechol-O-methyl-transferase.

Technical Data

Soluble to 100 mM in ethanol and to 100 mM in DMSO
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Mannisto and Kaakola (1990) Rationale for selective COMT inhibitors as adjuncts in the drug treatment of Parkinson's disease. Pharmacol.Toxicol. 66 317. PMID: 2196554.

Borgulya et al (1989) Catechol-O-methyltransferase-inhibiting pyrocatechol derivatives: synthesis and structure-activity studies. Helv.Chim.Acta 72 952.

If you know of a relevant reference for OR-486 please let us know.

Citations are publications that use Tocris products. Selected citations for OR-486 include:

Oróstica et al (2014) Estradiol increases cAMP in the oviductal secretory cells through a nongenomic mechanism. Reproduction 148 285. PMID: 25038866.

Do you know of a great paper that uses OR-486 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: OR-486, supplier, Catechol, O-methyl, transferase, COMT, inhibitors, inhibits, Tocris Bioscience, Catechol O-Methyltransferase Inhibitor products

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