NNC 55-0396 dihydrochloride

Cat. No. 2268

NNC 55-0396 dihydrochloride C30H38FN3O2.2HCl [357400-13-6]

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Chemical Name: (1S,2S)-2-[2-[[3-(1H-Benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl cyclopropanecarboxylate dihydrochloride

Biological Activity

Highly selective T-type calcium channel blocker. Displays IC50 values of 6.8 and > 100 μM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells.

Technical Data

M.Wt:
564.57
Formula:
C30H38FN3O2.2HCl
Solubility:
Soluble to 25 mM in water
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
357400-13-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Chen et al (2010) CaV3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain. J.Neurosci. 30 10360. PMID: 20685979.

Huang et al (2004) NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: A new selective inhibitor of T-type calcium channels. J.Pharmacol.Exp.Ther. 309 193. PMID: 14718587.

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Citations are publications that use Tocris products. Selected citations for NNC 55-0396 dihydrochloride include:

Senadheera et al (2013) Enhanced contractility in pregnancy is associated with augmented TRPC3, L-type, and T-type voltage-dependent calcium channel function in rat uterine radial artery. Proc Natl Acad Sci U S A 305 R917. PMID: 23948776.

Baillie et al (2012) Sumatriptan inhibition of N-type calcium channel mediated signaling in dural CGRP terminal fibres. Am J Physiol Regul Integr Comp Physiol 63 362. PMID: 22691374.

Tzeng et al (2012) The Ca(v)3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice. Cardiovasc Res 96 533. PMID: 22886848.

Abe et al (2011) The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells. PLoS One 108 12497. PMID: 21746923.

Kuo et al (2010) Dihydropyridine-insensitive calcium currents contribute to function of small cerebral arteries. J Cereb Blood Flow Metab 30 1226. PMID: 20125181.

Do you know of a great paper that uses NNC 55-0396 dihydrochloride from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: NNC 55-0396 dihydrochloride, supplier, selective, Ca2+, channel, blockers, T-type, Calcium, CaV, Channels, T-Type, voltage-gated, voltage-dependent, NNC550396, dihydrochloride, Tocris Bioscience, Voltage-gated Calcium Channel (CaV) Blocker products

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