Tandospirone hydrochloride

Cat. No. 2854

Tandospirone hydrochloride C21H29N5O2.HCl [99095-10-0]

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Alternative Name: SM-3997

Chemical Name: (3aR,4S,7R,7aS)-rel-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione hydrochloride

Biological Activity

5-HT1A receptor partial agonist (Ki = 27 nM) that displays selectivity over 5-HT2, 5-HT1C, α1, α2, D1 and D2 receptors (Ki values ranging from 1300 - 41000 nM). Inactive at 5-HT uptake sites, 5-HT1B, β-adrenergic, muscarinic and benzodiazepine receptors. Displays anxiolytic activity.

Technical Data

M.Wt:
419.95
Formula:
C21H29N5O2.HCl
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in water
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
99095-10-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Matsubara et al (2006) Tandospirone, a 5-HT1A agonist, ameliorates movement disorder via non-dopaminergic systems in rats with unilateral 6-hydroxydopamine-generated lesions. Brain Res. 1112 126. PMID: 16884702.

Pollard et al (1992) Effects of tandospirone in three behavioral tests for anxiolytics. Eur.J.Pharmacol. 221 297. PMID: 1358655.

Hamik et al (1990) Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites. Biol.Psychiatry 28 99. PMID: 1974152.

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Keywords: Tandospirone hydrochloride, supplier, Selective, 5-HT1A, partial, agonists, Serotonin, Receptors, SM3997, Tocris Bioscience, 5-HT1A Receptor Agonist products

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