DY131

Cat. No. 2266

DY131 C18H21N3O2 [95167-41-2]

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Chemical Name: N-(4-(Diethylaminobenzylidenyl)-N'-(4-hydroxybenzoyl)-hydrazine

Biological Activity

Novel selective agonist at estrogen-related receptors ERRβ and ERRγ. Displays minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μM.

Technical Data

M.Wt:
311.38
Formula:
C18H21N3O2
Solubility:
Soluble to 10 mM in ethanol and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
95167-41-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Yu and Forman (2005) Identification of an agonist ligand for estrogen-related receptors ERRβ/γ. Bioorg.Med.Chem.Lett. 15 1311. PMID: 15713377.

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Citations are publications that use Tocris products. Selected citations for DY131 include:

Lu et al (2015) Messenger RNA profile analysis deciphers new Esrrb responsive genes in prostate cancer cells. Neuropharmacology 16 21. PMID: 26627478.

Byerly et al (2013) Estrogen-related receptor β deletion modulates whole-body energy balance via estrogen-related receptor γ and attenuates neuropeptide Y gene expression. Eur J Neurosci 37 1033. PMID: 23360481.

Byerly et al (2013) Estrogen-related receptor β deficiency alters body composition and response to restraint stress. BMC Physiol 13 10. PMID: 24053666.

Gandhari et al (2010) Identification and characterization of estrogen receptor-related receptor alpha and gamma in human glioma and astrocytoma cells. Mol Cell Endocrinol 315 314. PMID: 19822186.

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Keywords: DY131, supplier, agonists, selective, estrogen-related, receptors, ERRβ, ERRbeta, ERRγ, ERRgamma, Estrogen, Receptors, ERRg, ERRb, Tocris Bioscience, Estrogen and Related Receptor Agonist products

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