Lyn peptide inhibitor
Cat. No. 2265
Biological ActivityCell-permeable inhibitor of Lyn-dependent effects of the IL-5 receptor. Blocks binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors, blocking Lyn activation. Inhibits IL-5 receptor-mediated eosinophil differentiation and survival in vitro. Inhibits airway eosinophilic inflammation in mouse model of asthma.
(Modifications: Tyr-1 = Octadecanoyl-Tyr, Pro-16 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Adachi et al (1999) The mapping of the Lyn kinase binding site of the common β subunit of IL-3/granulocyte-macrophage colony-stimulating factor/IL-5 receptor. J.Immunol. 162 1496. PMID: 9973406.
Adachi et al (1999) A novel lyn-binding peptide inhibitor blocks eosinophil differentiation, survival, and airway eosinophilic inflammation. J.Immunol. 163 939. PMID: 10395690.
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Keywords: Lyn peptide inhibitor, supplier, inhibitors, inhibits, Lyn, activation, IL-5, receptor, IL-3, Src, kinases, IL, receptors, Interleukin, cytokine, Tocris Bioscience, Cytokine Receptor products
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