Motilin (human, porcine)

Cat. No. 2264

Motilin (human, porcine) Phe-Val-Pro-Ile-Phe-Thr-Tyr-Gly-Glu-Leu-Gln-Arg-Met-Gln-Glu-Lys-Glu-Arg-Asn-Lys-Gly-Gln

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Biological Activity

Endogenous motilin receptor ligand (Ki = 2.3 nM) that regulates gastrointestinal motor function. Stimulates contraction of gut smooth muscle (EC50 = 1 nM) and increases pepsin release.

Technical Data

M.Wt:
2699.07
Formula:
C120H188N34O35S
Sequence:
FVPIFTYGELQRMQEKERNKGQ
Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
52906-92-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Huang et al (2005) Signaling pathways mediating gastrointestinal smooth muscle contraction and MLC20 phosphorylation by motilin receptors. Am.J.Physiol.Gastrointest.Liver Physiol. 288 G23. PMID: 15591586.

Coulie et al (2001) Identification of peptide ligand-binding domains within the human motilin receptor using photoaffinity labeling. J.Biol.Chem. 276 35518. PMID: 11461914.

Itoh (1997) Motilin and clinical application. Peptides 18 593. PMID: 9210180.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Motilin (human, porcine) include:

Broad and Sanger (2013) The antibiotic azithromycin is a motilin receptor agonist in human stomach: comparison with erythromycin. Br J Pharmacol 168 1859. PMID: 23190027.

Do you know of a great paper that uses Motilin (human, porcine) from Tocris? If so please let us know.

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Keywords: Motilin (human, porcine), supplier, Endogenous, peptide, regulator, gastrointestinal, motility, Motilin, Receptors, Tocris Bioscience, Motilin Receptor Agonist products

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