Cat. No. 2262
Alternative Name: WRW4
Biological ActivitySelective antagonist of formyl peptide receptor 2 (FPR2) signaling. Inhibits WKYMVm binding to FPR2 (IC50 = 0.23 μM) and inhibits intracellular calcium release induced by WKYMVm, MMK 1, amyloid β42, and F peptide. Also inhibits FPR2-mediated signaling in human neutrophils; blocks chemotactic migration and superoxide generation by amyloid β42 peptide.
(Modifications: Trp-6 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Bae et al (2004) Identification of peptides that antagonize formyl peptide receptor-like 1-mediating signaling. J.Immunol. 173 607. PMID: 15210823.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for WRW4 include:
Barnig et al (2013) Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma. Sci Transl Med 5 174ra26. PMID: 23447017.
Leoni et al (2013) Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest 123 443. PMID: 23241962.
Tristão et al (2013) 5-Lipoxygenase activity increases susceptibility to experimental Paracoccidioides brasiliensis infection. Infect Immun 81 1256. PMID: 23381993.
Do you know of a great paper that uses WRW4 from Tocris? If so please let us know.
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Keywords: WRW4, supplier, Selective, FPR2, antagonists, FPRL, Formyl, Peptide, Receptors, Tocris Bioscience, Formyl Peptide Receptor Antagonist products
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