Cat. No. 2260
Biological ActivityNon-acylated, major circulating isoform of ghrelin that does not bind to the ghrelin receptor (GHS-R1a), nor induce growth hormone release. However, exerts negative inotropic effects in papillary muscle and displays cardioprotective activity. Inhibits cell proliferation in breast and prostate cancer cell lines. Promotes adipogenesis in vivo.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Cassoni et al (2004) Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines. Eur.J.Endocrinol. 150 173. PMID: 14763915.
Thompson et al (2004) Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor. Endocrinology 145 234. PMID: 14551228.
Bedendi et al (2003) Cardiac effects of ghrelin and its endogenous derivatives des-octanoyl ghrelin and des-Gln14-ghrelin. Eur.J.Pharmacol. 476 87. PMID: 12969753.
Baldanzi et al (2002) Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. J.Cell Biol. 159 1029. PMID: 12486113.
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Keywords: [Des-Octanoyl]-Ghrelin (human), supplier, circulating, ghrelin, devoid, activity, receptors, active, in, vivo, GHS-R1a, Growth, Hormone, Secretagog, 1a, Ghrelin, Tocris Bioscience, Ghrelin Receptor products
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