L803-mts

Cat. No. 2256

L803-mts Myr-Gly-Lys-Glu-Ala-Pro-Pro-Ala-Pro-Pro-Gln-pSer-Pro-NH2

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Biological Activity

Selective peptide inhibitor of glycogen synthase kinase-3 (GSK-3). Produces antidepressive behavior in mice when administered in vivo. Shows no inhibition of PKC, PKB or cdc2 protein kinase. Exhibits insulin mimetic activity. Activates glycogen synthase activity 2.5-fold in HEK293 cells. Myristoylated version of L803 (Cat. No. 2235).

Licensing Information

Sold under licence from Tel Aviv University Future Technology LP.

Technical Data

M.Wt:
1464.64
Formula:
C66H110N15O20P
Sequence:
GKEAPPAPPQSP

(Modifications: Gly-1 = Myr-Gly, Pro-12 = C-terminal amide, Ser-11 = pSer)

Solubility:
Soluble to 1 mg/ml in 20% acetonitrile / water
Storage:
Store at -20°C
CAS No:
1043881-55-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Chen et al (2004) Glycogen syntase kinase 3β (GSK3β) mediates 6-hydroxydopamine-induced neuronal death. FASEB J. 18 1162. PMID: 15132987.

Kaidanovich-Beilin et al (2004) Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effects on β-catenin in mouse hippocampus. Biol.Psychiatry 55 781. PMID: 15050857.

Plotkin et al (2003) Insulin mimetic action of synthetic phosphorylated peptide inhibitiors of glycogen synthase kinase-3. J.Pharm.Exp.Ther. 305 974.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for L803-mts include:

Hill et al (2015) Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter. Int J Obes (Lond) 45 1103. PMID: 25627813.

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Keywords: L803-mts, supplier, L803-mts, peptides, inhibitors, glycogen, synthase, kinase-3, GSK-3, GSK3, inhibits, myristotylated, Tocris Bioscience, Glycogen Synthase Kinase 3 Inhibitor products

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