CGS 9343B

Cat. No. 2255

CGS 9343B C26H28N4O2.C4H4O4 [109826-27-9]

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Alternative Name: Zaldaride maleate

Chemical Name: 1,3-Dihydro-1-[1-[(4-methyl-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl)methyl]-4-piperidinyl]-2H-benzimidazol-2-one maleate

Biological Activity

Calmodulin antagonist; inhibits calmodulin-stimulated cAMP phosphodiesterase activity with an IC50 of 3.3 nM. Also prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na+, Ca2+ and K+ currents in PC12 cells and inhibits nAChR.

Technical Data

M.Wt:
544.61
Formula:
C26H28N4O2.C4H4O4
Solubility:
Soluble to 50 mM in DMSO and to 10 mM in ethanol with gentle warming
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
109826-27-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Li et al (2003) Calmodulin regulates the transcriptional activity of estrogen receptors. J.Biol.Chem. 278 1195. PMID: 12419798.

Neuhaus and Reber (1992) Inhibition of membrane currents and rises of intracellular Ca2+ in PC12 cells by CGS 9343B, a calmodulin inhibitor. Eur.J.Pharmacol. 226 183. PMID: 1379190.

Norman et al (1987) CGS 9343B, a novel, potent, and selective inhibitor of Calmodulin activity. Mol.Pharmacol. 31 535. PMID: 3033469.

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Keywords: CGS 9343B, supplier, Calmodulin, antagonists, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, CGS9343B, Tocris Bioscience, Calcium Binding Protein Modulator Antagonist products

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