Cat. No. 2254
Chemical Name: 3-Amino-6-chloro-5-dimethylamino-N-
Biological ActivityAntagonist at the mGlu5 receptor (Ki = 295 nM). Inhibits human mGlu5 receptor-mediated calcium flux with an IC50 of 134 nM.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Wang et al (2008) Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors. J.Neurosci. 28 4385. PMID: 18434517.
Bonnefous et al (2005) Dipyridyl amides: potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists. Bioorg.Med.Chem.Lett. 15 1197. PMID: 15686941.
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Citations are publications that use Tocris products.
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Keywords: ACDPP hydrochloride, supplier, Selective, mGlu5, mGluR5, receptor, antagonists, mGlur, Group, I, Receptors, Glutamate, Metabotropic, Tocris Bioscience, Glutamate (Metabotropic) Group I Receptor Antagonist products