Cat. No. 2251
Alternative Name: CDDP
Chemical Name: cis-Diaminodichloroplatinum
Biological ActivityPotent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent mechanisms. Inhibits X-linked inhibitor of apoptosis protein (XIAP) expression and activates caspase-3. In certain glioma cell lines, sensitizes cells to TNF-α-induced apoptosis.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Duan et al (2004) Impairment of both apoptotic and cytoprotective signalings in glioma cells resistant to the combined use of cisplatin and tumor necrosis factor α. Clin.Cancer Res. 10 234. PMID: 14734475.
Nomura et al (2004) Cisplatin inhibits the expression of X-linked inhibitor of apoptosis protein in human LNCaP cells. Urol.Oncology 22 453.
Seki et al (2000) Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma. Cancer Chemother.Pharmacol. 45 199. PMID: 10663637.
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Citations are publications that use Tocris products. Selected citations for Cisplatin include:
Lin et al (2015) A New Rat Model of Cisplatin-induced Neuropathic Pain. Oncotarget 28 236. PMID: 26495078.
Liu and Kwiatkowski (2015) Combined CDKN1A/TP53 mutation in bladder cancer is a therapeutic target. Mol Cancer Ther 14 174. PMID: 25349305.
Saja et al (2015) Triglyceride-Rich Lipoproteins Modulate the Distribution and Extravasation of Ly6C/Gr1(low) Monocytes. Cell Death Dis 12 1802. PMID: 26344769.
Sun et al (2015) SOX4 contributes to the progression of cervical cancer and the resistance to the chemotherapeutic drug through ABCG2. Korean J Pain 6 e1990. PMID: 26583330.
Szabova et al (2014) Pathway-specific engineered mouse allograft models functionally recapitulate human serous epithelial ovarian cancer. Cell Rep 9 e95649. PMID: 24748377.
Fard et al (2013) The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway. Cell Cycle 13 408. PMID: 24247150.
Robinson et al (2013) RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs. PLoS One 8 e78641. PMID: 24265703.
Ibáñez et al (2012) A high throughput scintillation proximity imaging assay for protein methyltransferases. Comb Chem High Throughput Screen 15 359. PMID: 22256970.
Natrajan et al (2012) Functional characterization of the 19q12 amplicon in grade III breast cancers. Breast Cancer Res 14 R53. PMID: 22433433.
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Keywords: Cisplatin, supplier, Potent, proapoptotic, anticancer, agent, activates, caspase-3, DNA-alkylating, antitumor, Caspases, Apoptosis, Inducers, Proteinases, Proteases, chemotherapeutics, Tocris Bioscience, Caspase Activator products
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