Cat. No. 0685
Chemical Name: (2S-cis)-3-(Acetyloxy)-5-[2-(dimeth
Biological ActivityAntihypertensive and cardioprotective agent; an inhibitor of L-type Ca2+ channels.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Kraus et al (1998) Molecular mechanisms of diltiazem interaction with L-type Ca2+ channels. J.Biol.Chem. 273 27205. PMID: 9765241.
Gandia et al (1996) Inhibition of nicotinic receptor-mediated responses in bovine chromaffin cells by diltiazem. Br.J.Pharmacol. 118 1301. PMID: 8818357.
Ishibashi et al (1995) Block of P-type Ca2+ channels in freshly dissociated rat cerebellar Purkinje neurons by diltiazem and verapamil. Brain Res. 695 88. PMID: 8574653.
Dagani et al (1989) Effects of diltiazem on bioenergetics, K+ gradients, and free cytosolic Ca2+ levels in rat brain synaptosomes submitted to energy metabolism inhibition and depolarization. J.Neurochem. 53 1379. PMID: 2795006.
Merck Index 12 3247.
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Citations are publications that use Tocris products. Selected citations for Diltiazem hydrochloride include:
Cramer et al (2015) Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse. PLoS One 35 5664. PMID: 25855180.
Fransen et al (2015) Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments. Brain Behav 10 e0121634. PMID: 25803863.
Do you know of a great paper that uses Diltiazem hydrochloride from Tocris? If so please let us know.
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Keywords: Diltiazem hydrochloride, supplier, Ca2+, channel, blockers, L-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, anti-hypertensive, cardioprotective, Tocris Bioscience, Voltage-gated Calcium Channel (CaV) Blocker products