N-Desmethylclozapine

Cat. No. 1007

N-Desmethylclozapine C17H17ClN4 [6104-71-8]

Price and Availability

For N-Desmethylclozapine pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Names: Normethylclozapine, Norclozapine

Chemical Name: 8-Chloro-11-(1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine

Biological Activity

A major metabolite of clozapine; a potent and selective 5-HT2C serotonin receptor antagonist.

Technical Data

M.Wt:
312.8
Formula:
C17H17ClN4
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
6104-71-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

Fox and Brotchie (1996) Normethylclozapine potentiates the action of quinpirole in the 6-hydroxydopamine lesioned rat. Eur.J.Pharmacol. 301 27. PMID: 8773443.

Wong et al (1996) Effects of clozapine metabolites and chronic clozapine treatment on rat brain GABAA receptors. Eur.J.Pharmacol. 314 319. PMID: 8957253.

Kuoppamäki et al (1993) Clozapine and methylclozapine are potent 5-HT1C receptor antagonists. Eur.J.Pharmacol. 245 179. PMID: 8387927.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for N-Desmethylclozapine include:

Gregory et al (2010) Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias. J Biol Chem 285 7459. PMID: 20051519.

Magliaro and Saldanha (2009) Clozapine protects PC-12 cells from death due to oxidative stress induced by hydrogen peroxide via a cell-type specific mechanism involving inhibition of extracellular signal-regulated kinase phosphorylation. Brain Res 1283 14. PMID: 19501068.

Sur et al (2003) N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity. Proc Natl Acad Sci U S A 100 13674. PMID: 14595031.

Do you know of a great paper that uses N-Desmethylclozapine from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: N-Desmethylclozapine, supplier, 5-HT2C, antagonists, Serotonin, Receptors, Norclozapine, Tocris Bioscience, 5-HT2C Receptor Antagonist products

Quick Order

Find multiple products by catalog number

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs Request copy or view PDF today.

divider line

5-HT Review

Written by N. Barnes & J. Neumaler

5-HT Receptors Scientific Review

Our 5-HT review summarizes the serotonin receptor subtypes and highlights their importance in mediating various physiological & pharmacological processes. Request copy or view PDF today.

divider line

Parkinson's disease: Neurobiology and Therapeutic Strategies

Written by Anthony H.V. Schapira

Parkinson's Life Science Poster

Our Parkinson's disease (PD) poster summarizes the neurobiology of the disease, and highlights current therapeutic treatments for symptomatic PD. Request copy or view PDF today.

divider line

Antidepressants - Current and Future Targets

Written by P. Skolnich et al

Depression Life Science Poster

Our Depression poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder. Request copy or view PDF today.

divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.