Cat. No. 1007
Alternative Names: Normethylclozapine, Norclozapine
Chemical Name: 8-Chloro-11-(1-piperazinyl)-5H-dibe
Biological ActivityA major metabolite of clozapine; a potent and selective 5-HT2C serotonin receptor antagonist.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Fox and Brotchie (1996) Normethylclozapine potentiates the action of quinpirole in the 6-hydroxydopamine lesioned rat. Eur.J.Pharmacol. 301 27. PMID: 8773443.
Wong et al (1996) Effects of clozapine metabolites and chronic clozapine treatment on rat brain GABAA receptors. Eur.J.Pharmacol. 314 319. PMID: 8957253.
Kuoppamäki et al (1993) Clozapine and methylclozapine are potent 5-HT1C receptor antagonists. Eur.J.Pharmacol. 245 179. PMID: 8387927.
If you know of a relevant reference for N-Desmethylclozapine please let us know.
Citations are publications that use Tocris products. Selected citations for N-Desmethylclozapine include:
Gregory et al (2010) Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias. J Biol Chem 285 7459. PMID: 20051519.
Magliaro and Saldanha (2009) Clozapine protects PC-12 cells from death due to oxidative stress induced by hydrogen peroxide via a cell-type specific mechanism involving inhibition of extracellular signal-regulated kinase phosphorylation. Brain Res 1283 14. PMID: 19501068.
Sur et al (2003) N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity. Proc Natl Acad Sci U S A 100 13674. PMID: 14595031.
Do you know of a great paper that uses N-Desmethylclozapine from Tocris? If so please let us know.
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Keywords: N-Desmethylclozapine, supplier, 5-HT2C, antagonists, Serotonin, Receptors, Norclozapine, Tocris Bioscience, 5-HT2C Receptor Antagonist products