Octopamine hydrochloride

Cat. No. 2242

Octopamine hydrochloride C8H11NO2.HCl [770-05-8]

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Alternative Names: (±)-p-Octopamine, Epirenor, Norfen

Chemical Name: α-(Aminomethyl)-4-hydroxybenzenemethanol hydrochloride

Biological Activity

Invertebrate biogenic amine neurotransmitter, related to noradrenalin, that is an adrenoceptor agonist. Stimulates lipolysis in mammalian adipocytes via activation of β3 receptors. Has dual effect on glucose transport in adipocytes: inhibits transport via β3 receptor activation but stimulates transport when oxidized by MAO. Also activates human α2A receptors, inhibiting subsequent cAMP production.

Technical Data

M.Wt:
189.64
Formula:
C8H11NO2.HCl
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
770-05-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Visentin et al (2001) Dual action of octopamine on glucose transport into adipocytes: inhibition via β3-adrenoceptor activation and stimulation via oxidation by amine oxidases. J.Pharmacol.Exp.Ther. 299 96. PMID: 11561068.

Carpene et al (1999) Selective activation of β3-adrenoceptors by octopamine: comparative studies in mammalian fat cells. Naunyn-Schmied.Arch.Pharmacol. 359 310.

Roeder (1999) Octopamine in invertebrates. Prog.Neurobiol. 59 533. PMID: 10515667.

Airriess et al (1997) Selective inhibition of adenylyl cyclase by octopamine via a human cloned α2A-adrenoceptor. Br.J.Pharmacol. 122 191. PMID: 9313925.

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