Cat. No. 2241
Chemical Name: 4-[(5,6-Dihydro[2,3'-bipyridin]-3(4H
Biological ActivityPartial agonist at α7-containing neuronal nicotinic receptors and antagonist at α4β2 and other nicotinic receptors. Displays specific cognition-enhancing effects; improves long-term memory in rats.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Stevens et al (1998) Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice. Psychopharmacology 136 320. PMID: 9600576.
Kem et al (1997) Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors. J.Pharmacol.Exp.Ther. 283 979. PMID: 9399967.
Arendash et al (1995) Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21. Brain Res. 674 252. PMID: 7796104.
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Keywords: DMAB-anabaseine dihydrochloride, supplier, Partial, agonists, α7, alpha7-containing, a7, receptors, antagonists, α4β2, a4b2, neuronal, nicotinic, Nicotinic, Receptors, Acetylcholine, nAChR, Tocris Bioscience, Nicotinic (α7) Receptor Agonist products
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Potent positive allosteric modulator of α4β2 nAChRs; also inhibitor of (α4)2(β2)3, muscle-type and Torpedo nAChRs
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