Dihydrokainic acid

Cat. No. 0111

Dihydrokainic acid C10H17NO4 [52497-36-6]

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Chemical Name: (2S,3S,4R)-2-Carboxy-4-isopropyl-3-pyrrolidineacetic acid

Biological Activity

EAAT2(GLT1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake (Ki = 23 μM). 130-fold selective over EAAT1 and EAAT3 (Ki > 3 mM). Also available as part of the Excitatory Amino Acid Transporter Inhibitor Tocriset™.

Technical Data

M.Wt:
215.25
Formula:
C10H17NO4
Solubility:
Soluble to 25 mM in water
Storage:
Store at RT
CAS No:
52497-36-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Arriza et al (1994) Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. J.Neurosci. 14 5559. PMID: 7521911.

Kanal et al (1994) The neuronal and epithelial high affinity glutamate transporter, insights into structure and mechanism of transport. J.Biol.Chem. 269 20599. PMID: 7914198.

Munoz et al (1987) Effects of dihydrokainic acid on extracellular amino acids and neuronal excitability in the in vivo rat hippocampus. Neuropharmacology 26 1. PMID: 2882438.

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Citations are publications that use Tocris products. Selected citations for Dihydrokainic acid include:

McKeown et al (2012) Disruption of Eaat2b, a glutamate transporter, results in abnormal motor behaviors in developing zebrafish. Dev Biol 362 162. PMID: 22094018.

Parri et al (2010) Sensory and cortical activation of distinct glial cell subtypes in the somatosensory thalamus of young rats. Eur J Neurosci 32 29. PMID: 20608967.

David et al (2009) Astrocytic dysfunction in epileptogenesis: consequence of altered potassium and glutamate homeostasis? J Neurosci 29 10588. PMID: 19710312.

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Keywords: Dihydrokainic acid, supplier, EAAT2, GLT-1-selective, non-transportable, inhibitors, inhibits, L-glutamate, L-aspartate, uptake, Excitatory, Amino, Acid, Transporters, Monoamine, Neurotransmitter, Tocris Bioscience, Glutamate Transporter Inhibitor products

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