Dihydroergotamine mesylate

Cat. No. 0475

Dihydroergotamine mesylate C33H37N5O5.CH3SO3H [6190-39-2]

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Chemical Name: 9,10-Dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotaman-3',6',18-trione mesylate

Biological Activity

Partial α-adrenergic agonist. Partial D2 dopaminergic receptor agonist. Competitive 5-HT antagonist.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Lesage et al (1998) Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines. Br.J.Pharmacol. 123 1655. PMID: 9605573.

Doggrell et al (1992) Further analysis of the inhibitory effects of dihydroergotamine, cyproheptadine and ketanserin on the responses of the rat aorta to 5-hydroxytryptamine. J.Auton.Pharmacol. 12 223. PMID: 1512277.

Villalon et al (1992) Effects of S9977 and dihydroergotamine in an animal experimental model for migraine. Pharmacol.Res. 25 125. PMID: 1635891.

de Boer et al (1991) Carotid vascular effects of ergotamine and dihydroergotamine in the pig: no exclusive mediation via 5-HT1-like receptors. Br.J.Pharmacol. 104 183. PMID: 1664762.

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Keywords: Dihydroergotamine mesylate, supplier, 5-HT, antagonists, partial, agonists, a-adrenergic, α-adrenergic, alpha-adrenergic, dopaminergic, D2, receptors, Partial, D2-like, alpha, Non-Selective, Serotonin, 5-HT3, Receptors, 5-Hydroxytryptamine, Dopamine, α-adrenoceptors, α-adrenoceptor, alpha-adrenoceptors, a-adrenoceptors, Tocris Bioscience, Non-selective Adrenergic α Receptor Agonist products

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