BRL 50481

Cat. No. 2237

BRL 50481 C9H12N2O4S [433695-36-4]

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Chemical Name: N,N,2-Trimethyl-5-nitro-benzenesulfonamide

Biological Activity

Selective, substrate-competitive inhibitor of phosphodiesterase (PDE) 7 (Ki = 180 nM). Displays > 200-fold selectivity over PDE1B, PDE1C, PDE2, PDE3, PDE4A4 and PDE5.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data

M.Wt:
244.26
Formula:
C9H12N2O4S
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
433695-36-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Smith et al (2004) Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes. Mol.Pharmacol. 66 1679. PMID: 15371556.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for BRL 50481 include:

Zhai et al (2012) β-Adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells. PLoS One 7 e47826. PMID: 23094097.

Morales-Garcia et al (2011) Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease. J Biol Chem 6 e17240. PMID: 21390306.

Do you know of a great paper that uses BRL 50481 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: BRL 50481, supplier, Selective, PDE7, inhibitors, inhibits, Phosphodiesterases, BRL50481, GlaxoSmithKline, GSK, Tocris Bioscience, Phosphodiesterase Inhibitor products

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