Cat. No. 2237
Chemical Name: N,N,2-Trimethyl-5-nitro-benzenesulf
Biological ActivitySelective, substrate-competitive inhibitor of phosphodiesterase (PDE) 7 (Ki = 180 nM). Displays > 200-fold selectivity over PDE1B, PDE1C, PDE2, PDE3, PDE4A4 and PDE5.
Licensing InformationSold with the permission of GlaxoSmithKline
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Smith et al (2004) Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes. Mol.Pharmacol. 66 1679. PMID: 15371556.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for BRL 50481 include:
Zhai et al (2012) β-Adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells. PLoS One 7 e47826. PMID: 23094097.
Morales-Garcia et al (2011) Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease. J Biol Chem 6 e17240. PMID: 21390306.
Do you know of a great paper that uses BRL 50481 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: BRL 50481, supplier, Selective, PDE7, inhibitors, inhibits, Phosphodiesterases, BRL50481, GlaxoSmithKline, GSK, Tocris Bioscience, Phosphodiesterase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Fluorometric CYP450 substrateGaleterone
CYP17 inhibitor; also androgen receptor antagonistPF 04449613
Potent PDE9 inhibitor; brain penetrantEggmanone
Potent and selective PDE4 inhibitor; suppresses hedgehog signaling
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.