BADGE

Cat. No. 1326

BADGE C21H24O4 [1675-54-3]

Price and Availability

For BADGE pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: Bisphenol A diglycidyl ether

Chemical Name: 2,2-Bis[4-(2,3-epoxypropoxy)phenyl]propane

Biological Activity

PPARγ pure antagonist with micromolar affinity in 3T3-L1 and 3T3-F442A preadipocyte cells; selective over PPARδ and PPARα. Antagonizes the ability of rosiglitazone to stimulate transcriptional activity of PPARγ. Acts as a PPARγ agonist in an ECV304 cell line. Also produces PPARγ-independent apoptosis of tumor cells via several mechanisms. Active in vivo.

Technical Data

M.Wt:
340.42
Formula:
C21H24O4
Solubility:
Soluble to 50 mM in ethanol and to 100 mM in DMSO
Purity:
>90 %
Storage:
Desiccate at -20°C
CAS No:
1675-54-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

Cuzzocrea et al (2004) Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-γ, reduces acute inflammation. Eur.J.Pharmacol. 483 79. PMID: 14709329.

Fehlberg et al (2003) Bisphenol A diglycidyl ether-induced apoptosis involves Bax/Bid-dependent mitochondrial release of apoptosis-inducing factor (AIF), cytochrome c and Smac/DIABLO. Br.J.Pharmacol. 139 495. PMID: 12788809.

Bishop-Bailey et al (2000) Bisphenol A diglycidyl ether (BADGE) is a PPARγ agonist in an ECV304 cell line. Br.J.Pharmacol. 131 651. PMID: 11030710.

Wright et al (2000) A synthetic antagonist for the peroxisome proliferator-activated receptor γ inhibits adipocyte differentiation. J.Biol.Chem. 275 1873. PMID: 10636887.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses BADGE from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: BADGE, supplier, PPARγ, PPARgamma, antagonists, Peroxisome, Proliferator-activating, Receptors, PPARs, BisphenolA, diglycidyl, ether, Tocris Bioscience, PPARγ Antagonist products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Nuclear Receptors Product Listing

Nuclear Receptors Product Listing

Our Nuclear Receptors Listing highlights over 150 products for nuclear receptors. Request copy or view PDF today.

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

divider line

Bio-Techne Events

Neuroscience 2016

Neuroscience 2016

November 12 - 16, 2016

San Diego, CA, USA

Booth: 3217