L803

Cat. No. 2235

L803 Lys-Glu-Ala-Pro-Pro-Ala-Pro-Pro-Gln-pSer-Pro

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Biological Activity

Novel phosphopeptide derived from GSK-3 recognition motif that acts as a substrate-competitive inhibitor of GSK-3β (IC50 = 150 μM). Displays minimal inhibition of Cdc2, MAPK, PKA, CK2, PKCδ and PKB at 200 μM. Myristoylated version available (L803-mts, Cat. No. 2256).

Licensing Information

Sold under licence from Tel Aviv University Future Technology LP

Technical Data

M.Wt:
1198.23
Formula:
C50H80N13O19P
Sequence:
KEAPPAPPQSP

(Modifications: Ser-10 = pSer)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
348089-28-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Plotkin et al (2003) Insulin mimetic action of synthetic phosphorylated peptide inhibitors of glycogen synthase kinase-3. J.Pharmacol.Exp.Ther. 305 974. PMID: 12626660.

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Citations are publications that use Tocris products.

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View Related Products by Product Action

Keywords: L803, supplier, Substrate-competitive, inhibitors, inhibits, GSK-3, Glycogen, Synthase, Kinases, 3, Carbohydrate, Metabolism, Tocris Bioscience, Glycogen Synthase Kinase 3 Inhibitor products

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