Cat. No. 0884
Chemical Name: (±)-trans-10,11-Dihydroxy-5,6,6a,7,8
Biological ActivityA potent, full efficacy dopamine D1 agonist which shows no agonist activity at peripheral D2 receptors or adrenoceptors at doses which cause maximal stimulation of D1 sites. The compound appears to be fully bioavailable in brain and exhibits profound antiparkinsonism effects in vivo.
Licensing InformationSold under license, US Patent 5,047,536
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Kholi et al (1993) Dihydrexidine: a new potent peripheral dopamine D1 receptor agonist. Eur.J.Pharmacol. 235 31. PMID: 8100195.
Taylor et al (1991) Dihydrexidine, a full dopamine D1 agonist, reduces MPTP-induced parkinsonism in monkeys. Eur.J.Pharmacol. 199 389. PMID: 1680717.
Brewster et al (1990) Trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective dopamine D1 full agonist. J.Med.Chem. 33 1756. PMID: 1971308.
Lovenberg et al (1989) Dihydrexidine, a novel selective high potency, full dopamine D-1 receptor agonist. Eur.J.Pharmacol. 166 111. PMID: 2572425.
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Citations are publications that use Tocris products. Selected citations for Dihydrexidine hydrochloride include:
Smith et al (2005) Dopaminergic stimulation of local protein synthesis enhances surface expression of GluR1 and synaptic transmission in hippocampal neurons. Neuron 45 765. PMID: 15748851.
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Keywords: Dihydrexidine hydrochloride, supplier, Selective, D1-like, agonists, Dopamine, Receptors, D5, dopaminergic, Tocris Bioscience, D1 and D5 Receptor Agonist products