Cat. No. 0468
Chemical Name: N,N'-bis[3-(Ethylamino)propyl]-1,3-p
Biological ActivityHighly potent inducer of spermidine/spermine N1-acetyltransferase, able to increase enzyme activity 200-1000 fold.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Fogel-Petrovic et al (1997) Structural basis for differential induction of spermidine/spermine N1-acetyltransferase activity by novel spermine analogs. Mol.Pharmacol. 52 69. PMID: 9224814.
Porter et al (1993) Antitumour activity of N1,N12-bis(ethyl)-norspermine against human melanoma xenografts and possible biochemical correlates of drug action. Cancer Res. 53 581. PMID: 8425191.
Bernacki et al (1992) Antitumour activity of N1,N12-bis(ethyl)spermine homologs against human MALME-3 melanoma xenografts. Cancer Res. 52 2424. PMID: 1568212.
Libby et al (1991) Characterization of human spermidine spermine N1-acetyltransferase purified from cultured melanoma cells. Arch.Biochem.Biophys. 284 238. PMID: 1989509.
If you know of a relevant reference for N1,N11-Diethylnorspermine tetrahydrochloride please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses N1,N11-Diethylnorspermine tetrahydrochloride from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: N1,N11-Diethylnorspermine tetrahydrochloride, supplier, Spermine, spermidine, N1-acetyltransferase, potentiator, Acyltransferases, Transferases, Tocris Bioscience, Other Transferase products
Find multiple products by catalog number
New Products in this Area
Highly potent and SAM-competitive EZH2 inhibitorGSK 591 dihydrochloride
Potent and selective PRMT5 inhibitorTP 064
Potent and selective PRMT 4 inhibitor
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.