N1,N11-Diethylnorspermine tetrahydrochloride

Cat. No. 0468

N1,N11-Diethylnorspermine tetrahydrochloride C13H32N4.4HCl [156886-85-0]

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Chemical Name: N,N'-bis[3-(Ethylamino)propyl]-1,3-propanediamine tetrahydrochloride

Biological Activity

Highly potent inducer of spermidine/spermine N1-acetyltransferase, able to increase enzyme activity 200-1000 fold.

Technical Data

M.Wt:
390.27
Formula:
C13H32N4.4HCl
Solubility:
Soluble to 100 mM in water
Storage:
Store at RT
CAS No:
156886-85-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Fogel-Petrovic et al (1997) Structural basis for differential induction of spermidine/spermine N1-acetyltransferase activity by novel spermine analogs. Mol.Pharmacol. 52 69. PMID: 9224814.

Porter et al (1993) Antitumour activity of N1,N12-bis(ethyl)-norspermine against human melanoma xenografts and possible biochemical correlates of drug action. Cancer Res. 53 581. PMID: 8425191.

Bernacki et al (1992) Antitumour activity of N1,N12-bis(ethyl)spermine homologs against human MALME-3 melanoma xenografts. Cancer Res. 52 2424. PMID: 1568212.

Libby et al (1991) Characterization of human spermidine spermine N1-acetyltransferase purified from cultured melanoma cells. Arch.Biochem.Biophys. 284 238. PMID: 1989509.

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Citations are publications that use Tocris products.

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Keywords: N1,N11-Diethylnorspermine tetrahydrochloride, supplier, Spermine, spermidine, N1-acetyltransferase, potentiator, Acyltransferases, Transferases, Tocris Bioscience, Other Transferase products

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