BD 1008 dihydrobromide
Cat. No. 0511
Chemical Name: N-[2-(3,4-Dichlorophenyl)ethyl]-N-m
Biological ActivityPotent and selective σ-ligand (Ki against [3H]-(+)-3-PPP = 0.34 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Whittemore et al (1997) Antagonism of N-methyl-D-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J.Pharmacol.Exp.Ther. 282 326. PMID: 9223571.
Monnet et al (1996) Differentiation of σ ligand-activated receptor subtypes that modulate NMDA-evoked [3H]-noradrenaline release in rat hippocampal slices. Br.J.Pharmacol. 119 65. PMID: 8872358.
De Costa et al (1992) Synthesis, characterization, and biological evaluation of a novel class of N-(arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamines - structural requirements and binding affinity at the σ receptor. J.Med.Chem. 35 38. PMID: 1310114.
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Citations are publications that use Tocris products. Selected citations for BD 1008 dihydrobromide include:
Hiranita et al (2011) Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors. J Pharmacol Exp Ther 339 662. PMID: 21859929.
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