BD 1008 dihydrobromide

Cat. No. 0511

BD 1008 dihydrobromide C15H22Cl2N2.2HBr [138356-09-9]

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Chemical Name: N-[2-(3,4-Dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamine dihydrobromide

Biological Activity

Potent and selective σ-ligand (Ki against [3H]-(+)-3-PPP = 0.34 nM).

Technical Data

M.Wt:
463.08
Formula:
C15H22Cl2N2.2HBr
Solubility:
Soluble to 50 mM in water
Storage:
Store at -20°C
CAS No:
138356-09-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Whittemore et al (1997) Antagonism of N-methyl-D-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J.Pharmacol.Exp.Ther. 282 326. PMID: 9223571.

Monnet et al (1996) Differentiation of σ ligand-activated receptor subtypes that modulate NMDA-evoked [3H]-noradrenaline release in rat hippocampal slices. Br.J.Pharmacol. 119 65. PMID: 8872358.

De Costa et al (1992) Synthesis, characterization, and biological evaluation of a novel class of N-(arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamines - structural requirements and binding affinity at the σ receptor. J.Med.Chem. 35 38. PMID: 1310114.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for BD 1008 dihydrobromide include:

Hiranita et al (2013) Stimulants as specific inducers of dopamine-independentσ agonist self-administration in rats. Neurochem Int 347 42633. PMID: 23908387.

Hiranita et al (2011) Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors. J Pharmacol Exp Ther 339 662. PMID: 21859929.

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Keywords: BD 1008 dihydrobromide, supplier, Potent, selective, σ, sigma, ligand, General, Receptors, BD1008, dihydrobromide, Tocris Bioscience, Sigma-Related Ligand products

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