Cat. No. 0286
Chemical Name: 5,7-Dichloro-4-hydroxyquinoline-2-c
Biological ActivityPotent antagonist at the glycine site of the NMDA receptor (Ki = 79 nM vs. [3H]-glycine). Sodium salt (Cat. No. 3698) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
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Baron et al (1990) Activity of 5,7-dichlorokynurenic acid. A potent antagonist at the NMDA receptor-associated glycine binding site. Mol.Pharmacol. 38 554. PMID: 2172769.
Moore et al (1990) Substituted kynurenic acid derivatives. Potent and selective antagonists at the glycine site on the NMDA receptor. Eur.Fed.Med.Chem. (under auspices of IUPAC) XIth I 29.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for 5,7-Dichlorokynurenic acid include:
Astorga et al (2015) An excitatory GABA loop operating in vivo. Front Cell Neurosci 9 275. PMID: 26236197.
Stevens et al (2010) Light-evoked NMDA receptor-mediated currents are reduced by blocking D-serine synthesis in the salamander retina. Cell Commun Signal 21 239. PMID: 20101193.
Kenny et al (2009) The integrity of the glycine co-agonist binding site of N-methyl-D-aspartate receptors is a functional quality control checkpoint for cell surface delivery. J Biol Chem 284 324. PMID: 18990687.
Do you know of a great paper that uses 5,7-Dichlorokynurenic acid from Tocris? If so please let us know.
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Keywords: 5,7-Dichlorokynurenic acid, supplier, Potent, NMDA, antagonists, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Tocris Bioscience, NMDA Receptor Antagonist products