Cat. No. 2227
Chemical Name: 2,2-Dimethyl-N-(2,4,6-trimethoxyphe
Biological ActivitySelective acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor (IC50 = 0.073 μM). Lowers non-high density lipoprotein (HDL)-cholesterol and increases HDL-cholesterol concentrations in rats with pre-established dyslipidemia. Orally active. Also inhibits Golgi-associated LPL acyltransferase (LPAT) activity (IC50 = 15 μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Drecktrah et al (2003) Inhibition of a Golgi complex lysophospholipid acyltransferase induces membrane tubule formation and retrograde trafficking. Mol.Biol.Cell 14 3549.
Krause et al (1993) In vivo evidence that the lipid-regulating activity of ACAT inhibitor CI-976 in rats is due to inhibition of both intestinal and liver ACAT. J.Lipid Res. 34 279. PMID: 8429262.
Sliskovic and White (1991) Therapeutic potential of ACAT inhibitors as lipid lowering and anti-atherosclerotic agents. TiPS. 12 194.
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Citations are publications that use Tocris products. Selected citations for CI 976 include:
Pagliuso et al (2016) Golgi membrane fission requires the CtBP1-S/BARS-induced activation of lysophosphatidic acid acyltransferase δ Nature Communications 7 12148. PMID: 27401954.
Schmidt and Brown (2009) Lysophosphatidic acid acyltransferase 3 regulates Golgi complex structure and function. J Cell Biol 186 211. PMID: 19635840.
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Keywords: CI 976, supplier, Acyl-CoAcholesterol, acyltransferase, ACAT, inhibitors, inhibits, Transferases, CI976, Tocris Bioscience, Acyl-CoA:Cholesterol Acyltransferase Inhibitor products
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