Flutax 1

Cat. No. 2226

Flutax 1 C71H66N2O21 [191930-58-2]

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Chemical Name: (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-9-[(2R,3S)-3-(benzoylamino)-2-hydroxy-1-oxo-3-phenylpropoxy]-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-4-yl ester N-[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)carbonyl]-L-alanine

Biological Activity

A fluorescent taxol derivative that binds to the taxol microtubule binding site with high affinity (Ka ~ 107M-1). Useful for direct imaging of the microtubule cytoskeleton. Excitation maximum ~ 495 nm; emission maximum ~ 520 nm.

Technical Data

M.Wt:
1283.3
Formula:
C71H66N2O21
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
191930-58-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Diaz et al (2003) Fast kinetics of taxol binding to microtubules. J.Biol.Chem. 278 8407. PMID: 12496245.

Diaz et al (2000) Molecular recognition of taxol by microtubules. Kinetics and thermodynamics of binding of fluorescent taxol derivatives to an exposed site. J.Biol.Chem. 275 26265. PMID: 10818101.

Evangelio et al (1998) Fluorescent taxoids as probes of the microtubule cytoskeleton. Cell Motil.Cytoskel. 39 73.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Flutax 1 include:

Kaittanis et al (2014) Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching. Nat Commun 5 3384. PMID: 24594970.

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Keywords: Flutax 1, supplier, Fluorescent, taxol, derivative, Mitosis, Probes, Tau, Tubulin, Microtubules, Flutax1, Tocris Bioscience, Microtubule products

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