2,4-Diamino-6-hydroxypyrimidine

Cat. No. 0476

2,4-Diamino-6-hydroxypyrimidine C4H6N4O [56-06-4]

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Biological Activity

GTP cyclohydrolase I (GCH1) inhibitor. Prevents the de novo synthesis of tetrahydrobiopterin (BH4) and thus suppresses the activity of NO synthase. Exhibits more potent inhibition of GCH1 in the presence of GFRP (GTP cyclohydrolase feedback-regulatory protein).

Technical Data

M.Wt:
126.12
Formula:
C4H6N4O
Solubility:
Soluble in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
56-06-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Xie et al (1998) GTP cyclohydrolase I inhibition by the prototypic inhibitor 2,4-diamino-6-hydroxypyrimidine. J.Biol.Chem. 273 21091. PMID: 9694862.

Moore and Handy (1997) Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system? TiPs 18 204. PMID: 9226999.

Werner-Felmayer et al (1993) Pteridine biosynthesis in human endothelial cells. Impact of NO-mediated formation of cyclic GMP. J.Biol.Chem. 268 1842. PMID: 7678411.

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Keywords: 2,4-Diamino-6-hydroxypyrimidine, supplier, GTP, cyclohydrolase, I, inhibitor, GCH1, GTPCH, GCH, inhibitors, inhibits, biosynthesis, tetrahydrobiopterin, BH4, NOS, Nitric, Oxide, synthase, Signaling, Signalling, Tocris Bioscience, Other Nitric Oxide Inhibitor products

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