MNI caged kainic acid
Cat. No. 2225
Chemical Name: (2S,3S,4S)-Carboxy-4-(1-methylethen
Biological ActivityKainic acid (Cat.No. 0222) caged with the photosensitive 4-methoxy-7-nitroindolinyl group. Generates large inward currents at resting membrane potential upon wide field photolysis in Purkinje neurons. Selectively photoactivates kainate receptors when used in conjunction with an AMPA antagonist, such as GYKI 53655 (Cat.No. 2555). Suitable for uncaging with 300-380 nm excitation. Exhibits rapid uncaging rate relative to ionotropic glutamate receptor activation.
Licensing InformationSold under licence from the Medical Research Council
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Palma-Cerda et al (2013) New caged neurotransmitter analogues based on methoxy-nitroindole and nitrophenylethoxycarbonyl caging groups are selective for glutamate receptor subtypes. Neuropharmacology 63 624. PMID: 22609535.
Palma-Cerda et al (2012) New caged neurotransmitter analogs selective for glutamate receptor sub-types based on methoxynitroindoline and nitrophenylethoxycarbonyl caging groups. Neuropharmacology. 63 624. PMID: 22609535.
Maier et al (2005) Comparative analysis of inhibitor effects of caged ligands for the NMDA receptor. J.Neurosci.Meths. 142 1. PMID: 15652611.
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November 8 - 10, 2017