MNI-caged-NMDA

Cat. No. 2224

MNI-caged-NMDA C14H17N3O6 [1227675-52-6]

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Alternative Name: 4-Methoxy-7-nitroindolinyl-caged N-methyl-D-aspartic acid

Chemical Name: (R)-α-Methylamino-2,3-dihydro-4-methoxy-7-nitro-γ-oxo-1H-indole-1-butanoic acid

Biological Activity

NMDA (Cat.No. 0114) caged with the photosensitive 4-methoxy-7-nitroindolinyl group. Stoichiometrically releases chirally pure NMDA. Suitable for uncaging with 300-380 nm excitation. Improved localization can be achieved by uncaging at 405 nm (with mM concentration of caged compound in the bath solution). Exhibits rapid uncaging rate relative to ionotropic glutamate receptor activation.

Licensing Information

Sold under license from the UK Medical Research Council

Technical Data

M.Wt:
323.3
Formula:
C14H17N3O6
Solubility:
Soluble to 5 mM in water with gentle warming and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
1227675-52-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Palma-Cerda et al (2012) New caged neurotransmitter analogs selective for glutamate receptor sub-types based on methoxynitroindoline and nitrophenylethoxycarbonyl caging groups. Neuropharmacology. 63 624. PMID: 22609535.

If you know of a relevant reference for MNI-caged-NMDA please let us know.

Citations are publications that use Tocris products. Selected citations for MNI-caged-NMDA include:

Zhang et al (2016) Stereotyped initiation of retinal waves by bipolar cells via presynaptic NMDA autoreceptors. Nat.Commun. 7 12650. PMID: 27586999.

Do you know of a great paper that uses MNI-caged-NMDA from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: MNI-caged-NMDA, supplier, Caged, NMDA, Compounds, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, MNI-NMDA, Tocris Bioscience, Photolysis products

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