Dantrolene, sodium salt

Cat. No. 0507

Dantrolene, sodium salt C14H9N4NaO5 [14663-23-1]

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Chemical Name: 1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolinedione sodium salt

Biological Activity

Inhibits release of Ca2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor (RYR) channels. Displays selectivity for RYR1 and RYR3 over RYR2. Protective against the effects of a variety of conditions and agents, including excitatory amino acids. Skeletal muscle relaxant and neuroprotectant.

Technical Data

M.Wt:
336.23
Formula:
C14H9N4NaO5
Solubility:
Soluble to 10 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
14663-23-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Zhao et al (2001) Dantrolene inhibition of ryanodine receptor Ca2+ release channels. J.Biol.Chem. 276 13810. PMID: 11278295.

O'Mara et al (1995) Dantrolene inhibits long-term depression and depotentiation of synaptic transmission in the rat dentate gyrus. Neuroscience 68 621. PMID: 8577362.

Hotchkiss and Karl (1994) Dantrolene ameliorates the metabolic hallmarks of sepsis in rats and improves survival in a mouse model of endotoxemia. Proc.Natl.Acad.Sci.U.S.A. 91 3039. PMID: 8159702.

Merck Index 12 2879.

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Keywords: Dantrolene, sodium salt, supplier, Ca2+, release, inhibitors, inhibits, Calcium, Signaling, Signalling, Agents, General, ryanodine, receptors, ion, channels, Tocris Bioscience, Ryanodine Receptor Inhibitor products

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