Cat. No. 1156
Biological ActivitySensory neuropeptide and inflammatory mediator. Exerts excitatory effects on central and peripheral neurons, constricts bronchioles and is involved in pain transmission.
(Modifications: Met-11 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Andoh et al (1998) Substance P induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice. J.Pharmacol.Exp.Ther. 286 1140. PMID: 9732370.
Walsh et al (1995) Substance P-induced inflammatory responses in guinea-pig skin: the effect of specific NK1 receptor antagonists and the role of endogenous mediators. Br.J.Pharmacol. 114 1343. PMID: 7541689.
Pernow et al (1983) Substance P. Pharmacol.Rev. 35 85. PMID: 6196797.
Merck Index 12 9032.
If you know of a relevant reference for Substance P please let us know.
Citations are publications that use Tocris products. Selected citations for Substance P include:
Fisher et al (2015) Increased CCN2, substance P and tissue fibrosis are associated with sensorimotor declines in a rat model of repetitive overuse injury. J Cell Commun Signal 9 37. PMID: 25617052.
Hur and Park (2013) Long-term potentiation of excitatory synaptic strength in spinothalamic tract neurons of the rat spinal cord. Korean J Physiol Pharmacol 17 553. PMID: 24381506.
Robery et al (2011) Investigating the effect of emetic compounds on chemotaxis in Dictyostelium identifies a non-sentient model for bitter and hot tastant research. PLoS One 6 e24439. PMID: 21931717.
Shanley et al (2011) Evidence for regulatory diversity and auto-regulation at the TAC1 locus in sensory neurones. J Neurosci 8 10. PMID: 21294877.
Hanson et al (2009) A homogeneous fluorescent live-cell assay for measuring 7-transmembrane receptor activity and agonist functional selectivity through β-arrestin recruitment. Antioxid Redox Signal 14 798. PMID: 19531663.
Li et al (2009) Activation of glycogen synthase kinase-3 β is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex. J Neurosci 29 15551. PMID: 20007479.
Howe et al (2004) Role of neurokinin 3 receptors in supraoptic vasopressin and oxytocin neurons. J Biomol Screen 24 10103. PMID: 15537880.
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Keywords: Substance P, supplier, Sensory, neuropeptide, inflammatory, mediators, Tachykinin, Non-Selective, Neurokinin, Receptors, agonists, SubstanceP, neuropeptides, Tocris Bioscience, Other Tachykinin Agonist products