Cat. No. 1156
Biological ActivitySensory neuropeptide and inflammatory mediator. Exerts excitatory effects on central and peripheral neurons, constricts bronchioles and is involved in pain transmission.
(Modifications: Met-11 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Andoh et al (1998) Substance P induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice. J.Pharmacol.Exp.Ther. 286 1140. PMID: 9732370.
Walsh et al (1995) Substance P-induced inflammatory responses in guinea-pig skin: the effect of specific NK1 receptor antagonists and the role of endogenous mediators. Br.J.Pharmacol. 114 1343. PMID: 7541689.
Pernow et al (1983) Substance P. Pharmacol.Rev. 35 85. PMID: 6196797.
Merck Index 12 9032.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for Substance P include:
Fisher et al (2015) Increased CCN2, substance P and tissue fibrosis are associated with sensorimotor declines in a rat model of repetitive overuse injury. J Cell Commun Signal 9 37. PMID: 25617052.
Hur and Park (2013) Long-term potentiation of excitatory synaptic strength in spinothalamic tract neurons of the rat spinal cord. Korean J Physiol Pharmacol 17 553. PMID: 24381506.
Robery et al (2011) Investigating the effect of emetic compounds on chemotaxis in Dictyostelium identifies a non-sentient model for bitter and hot tastant research. PLoS One 6 e24439. PMID: 21931717.
Do you know of a great paper that uses Substance P from Tocris? If so please let us know.
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Keywords: Substance P, supplier, Sensory, neuropeptide, inflammatory, mediators, Tachykinin, Non-Selective, Neurokinin, Receptors, agonists, SubstanceP, neuropeptides, Tocris Bioscience, Other Tachykinin Agonist products
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