Cat. No. 1214
Chemical Name: 2-Methyl-6-(2-phenylethenyl)pyridin
Biological ActivityA highly selective non-competitive antagonist for the metabotropic glutamate mGlu5 receptor subtype; displays an IC50 value of 0.3 μM at hmGlu5, compared with > 100 μM at hmGlu1b, hmGlu2, hmGlu6, hmGlu7 and hmGlu8. Centrally active upon systemic administration in vivo. Positive allosteric modulator at mGlu4 receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Mathiesen et al (2003) Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP. Br.J.Pharmacol. 138 1026. PMID: 12684257.
Chapman et al (2000) Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893). Neuropharmacology 39 1567. PMID: 10854901.
Varney et al (1999) SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5. J.Pharmacol.Exp.Ther. 290 170. PMID: 10381773.
If you know of a relevant reference for SIB 1893 please let us know.
Citations are publications that use Tocris products. Selected citations for SIB 1893 include:
Edri et al (2015) Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors. Nat Commun 6 6500. PMID: 25799239.
Mathiesen et al (2003) Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP. Br J Pharmacol 138 1026. PMID: 12684257.
Do you know of a great paper that uses SIB 1893 from Tocris? If so please let us know.
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Keywords: SIB 1893, supplier, Positive, allosteric, modulators, mGlu4, mGluR4, mGlu5, mGluR5, antagonist, positive, Group, III, Receptors, Glutamate, Metabotropic, I, SIB1893, Tocris Bioscience, Glutamate (Metabotropic) Group I Receptor Antagonist products
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